Study finds risk of heart damage up 41%, but blames hypertension not drug
Babies born to women who suffer from high blood pressure in early pregnancy may be at higher risk of birth defects, according to research in the British Medical Journal.
Drugs taken by pregnant women for hypertension – angiotensin-converting enzyme (ACE) inhibitors – are known to have a toxic effect on unborn babies during the second or third trimesters.
But researchers led by Dr De-Kun Li of the Kaiser Foundation Research Institute in California sought to find out if taking ACE inhibitors in the first trimester caused birth defects. They studied the health records of 465,754 pairs of mothers and infants in California between 1995 and 2008, and concluded that while the drugs did not cause defects, the underlying hypertension itself could increase the risk.